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Will a mutation on the SENSE strand changes anything? During replication, it is only the ANTI-sense strand is transcribed.

1 year ago

Answered By Dr. Amandeep T

A mutation in the "sense" strand will affect the next generation if its in the "sense" strand of the DNA of germ cells, given the situation that the mutation does not get repaired by the DNA repair mechanisms of that cell.


1 year ago

Answered By Leora C

To add to Dr. Amandeep’s answer, yes, it could change things. It would be dependent upon which cells the mutation occurred in. If the mutation occurred in a germ cell, and wasn’t repaired, a mutation would show up in both the sense and anti-sense strands as that DNA is replicated due to the strands needing to form chemical bonds with one another. Even though the anti-sense strand is being transcribed, it must match up with the nucleotides of the sense strand. What would also matter would be if the DNA in question is in a coding region of the DNA (exon). 


1 year ago

Answered By Manasa R

In basic transcription, not ocnsidering anythign else, the mutation to the sense strand wont change anything, a mutation to the anti-sense strand definetly would change it because it would affect the amino acid that would pair with it (codon). 


1 year ago

Answered By manjula b

LET  US  BEGIN  WITH AN EXAMPLE  OF  MUTATION IN SENSE  STRAND   OF DNA , IF A SPELLING ERROR OCCURS (GCA –GCT) IN WHICH AN “A” IS REPLACED BY AT IN THS SENSE STRAND , CAUSING COMPLEMETERY  CHANGES  IN  THE ANTISENSE  DNA STRAND  ALSO.( CGT –CGA)

DURING  TRANSCRIPTION   m RNA CHANGES  FROM  GCA TO GCU.

BUT NO CHANCES OCCUR IN THE AMINO ACID BECAUSE OF THE INHERENT REDUNDANCY IN DNA CODE.

SO , ITS ALL DEPEND UPON THE TYPE OF CELL WHERE IN THE MUTATION TAKES PLACE : SOMATIC  OR GERM CELL .

MOST  SOMATIC  CELL MUTATION HAVE   NO  PRACTICLE  IMPACT ON THE ORGANISM.

IF MUTATION  TAKES  PLACE  IN GERM CELL THAT IS FERTILIZED , THE MUTATION IS PRESENT  IN ALL THE CELLS  OF THE OFFSPRING  AND  WELL  PASSED  ON TO THE NEXT  GENERATION.

 


1 year ago

Answered By manjula b

LET  US  BEGIN  WITH AN EXAMPLE  OF  MUTATION IN SENSE  STRAND   OF DNA , IF A SPELLING ERROR OCCURS (GCA –GCT) IN WHICH AN “A” IS REPLACED BY "T" IN THS SENSE STRAND , CAUSING COMPLEMETERY  CHANGES  IN  THE ANTISENSE  DNA STRAND  ALSO.( CGT –CGA)

DURING  TRANSCRIPTION   m RNA CHANGES  FROM  GCA TO GCU.

BUT NO CHANCES OCCUR IN THE AMINO ACID BECAUSE OF THE INHERENT REDUNDANCY IN DNA CODE.

SO , ITS ALL DEPEND UPON THE TYPE OF CELL WHERE IN THE MUTATION TAKES PLACE : SOMATIC  OR GERM CELL .

MOST  SOMATIC  CELL MUTATION HAVE   NO  PRACTICLE  IMPACT ON THE ORGANISM. 

IF MUTATION  TAKES  PLACE  IN GERM CELL THAT IS FERTILIZED , THE MUTATION IS PRESENT  IN ALL THE CELLS  OF THE OFFSPRING  AND  WELL  PASSED  ON TO THE NEXT  GENERATION.